Table 4. Association between presence of a pathogenic mutation or variant of unknown significance (VUS) in BRCA1-2 genes and PBL-TL: Multivariate linear regression analysis.

Parameter	Adjusted Difference	S.E.	95% C.L.	F (df)	P
Case/Control Status
Breast Cancer vs Controls	0.313	0.196	-0.075–0.702	2.549 (1)	0,113
BRCA Mutation Status
Mutated vs negative	-0.339	0.175	-0.685–0.008	2.235 (2)	0.112
VUS vs negative	-0.273	0.219	-0.706–0.160
AGE
<40 vs 40–55 vs 55–65 vs >65	-0.078	0.084	-0.245–0.089	0.860 (1)	0.356
Interaction between CC-status -BRCAa CC- mutational status CC-VUS	0.586 1.048	0.351 0.437	-0.109–1,280 0.182–1.914	3.568(2)	0.031
Interaction AGE-BRCAb	-	-	-	1.372 (2)	0.258
Interaction CC-Status Ageb	-	-	-	2.083 (1)	0.152

^a See Methods and Results for the explanation of the meaning and for the interpretation of the interaction coefficient

^b Excluded from the final model