Table 1. Baseline characteristic of survivors and non-survivors (30 days).
| Variable | Survivors n = 68 (63%) |
Non-survivors n = 40 (37%) |
P-value |
|---|---|---|---|
| Age yrs. (range/± SD) | 55.0 (24-82/±15.8) | 56.6 (18-86/±15.8) | 0.620 |
| Male gender (%) | 39 (57) | 25 (63) | 0.599 |
| Body mass index (kg/m2) | 27.3 (±5.8) | 26.9 (± 5.9) | 0.815 |
| Medical history, no. (%) | 0.927 | ||
| - Cardiovascular disease | 16 (24%) | 9 (23%) | |
| - Gastrointestinal disease | 20 (29%) | 11 (27%) | |
| - Gastrointestinal cancer | 4 (6%) | 2 (5%) | |
| - Hematooncological disease | 1 (1%) | 3 (8%) | |
| - Lung disease | 14 (21%) | 9 (23%) | |
| - Skin and soft tissue infection | 3 (4%) | 1 (2%) | |
| - Trauma | 2 (3%) | 1 (2%) | |
| - Urogenital disease | 5 (8%) | 3 (8%) | |
| - Other | 3 (4%) | 1 (2%) | |
| Dialysis (%) | 30 (44%) | 26 (65%) | 0.036 |
| Mechanical ventilation (%) | 47 (69%) | 29 (73%) | 0.710 |
| Horowitz-Index (PaO2/FiO2), (mmHg) | 286.5 [207–377] | 324 [188–382] | 0.807 |
| C-reactive protein concentration (mg/dl) | 11.7 [5.8–18.7] | 10.6 [3,7–20.2] | 0.566 |
| Procalcitonin concentration (ng/ml) | 3.1 [1.1–12.7] | 2.5 [1.0–18.3] | 0.752 |
| Interleukin-6 concentration (pg/ml) | 77.1 [22.1–146.5] | 234.0 [53.5–774.3] | 0.007 |
| Leukocyte concentration (109/l) | 12.5 [9.1–18.1] | 17.1 [10.6–22.3] | 0.108 |
| AST activity (U/l) | 59 [25–119] | 81 [37.5–524.5] | 0.006 |
| ALT activity (U/l) | 40 [20–96] | 49 [25–364.5] | 0.061 |
| Total bilirubin concentration (mg/dl) | 1.2 [0.5–2.2] | 1.9 [1.1–7.3] | 0.001 |
| LDH activity (U/l) | 349.5 [252.5–473] | 480 [217–1119] | 0.141 |
| INR | 1.2 [1.1–1.4] | 1.4 [1.1–1.7] | 0.034 |
| Platelet concentration (/nl) | 128 [72–196] | 102 [52–158.5] | 0.016 |
| SAPS II | 45.5 (±17.4) | 47.8 (±17.7) | 0.519 |
| SOFA-Score | 10.2 (±3.7) | 12.4 (±3.6) | 0.002 |
| Gram positive isolates only (%) | 29 (43%) | 14 (35%) | 0.689 |
| Gram negative isolates only (%) | 23 (34%) | 12 (30%) | |
| Mixed bacterial isolates (%) | 6 (9%) | 8 (20%) | |
| Viral isolates (%) | 0 (-) | 0 (-) | |
| Fungal isolates (%) | 1 (1%) | 1 (2%) | |
| Negative cultures (%) | 9 (13%) | 5 (13%) |
Data are presented as n (%); means (± SD), medians (25th, 75th percentile), AST: Aspartate aminotransferase ALT: Alanine aminotransferase, LDH: Lactate dehydrogenase, INR: International Normalized Ratio; SAPS II: Simplified Acute Physiology Score; SOFA: Sepsis-related Organ Failure Assessment score.