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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Am J Transplant. 2018 Feb 13;18(4):779–784. doi: 10.1111/ajt.14669

Figure 1.

Figure 1

Summary of B cell differentiation after primary (1°) or secondary (2°) antigen (Ag) encounter. Primary antigen encounter generates two waves of memory B cells (MemB) and antibody secreting cells. The early wave is prior to and independent of the germinal center (GC) response, and generates pre-GC MemB cells as well as short-lived plasmablasts (PB). The later wave generates a post-GC MemB and long-lived plasma cells (LL-PC). Upon a secondary Ag encounter, IgM+ and IgG+ memory B cells have distinct abilities to differentiate directly into secondary PB (mPB) or GC cells that undergo further B cell receptor diversification to ultimately emerge as secondary MemB or PCs. Width of blue lines indicates relative quantities of cell output.