Table 3.

Summary of studies that examined replication stress proteomes.

Study	Perturbation	Method	Number of replicates	Number of proteins
Sirbu, J Biol Chem 2013	Hydroxyurea	iPOND Label-free	5	139*
Sirbu, J Biol Chem 2013	Hydroxyurea + ATR inhibitor	iPOND Label-free	5	137*
Lossaint, Mol Cell 2013	Hydroxyurea	iPOND Label-free	3	n/a
Dungrawala, Mol Cell 2015	Hydroxyurea	iPOND-SILAC	18	192
Dungrawala, Mol Cell 2015	Aphidicollin	iPOND-SILAC	2	n/a
Dungrawala, Mol Cell 2015	Hydroxyurea + ATR inhibitor	iPOND-SILAC	11	151
Dungrawala, Mol Cell 2015	Aphidicolin + ATR inhibitor	iPOND-SILAC	2	n/a
Ribeyre, Cell Reports 2016	Camptothecin	iPOND-Label-free	6	21
Olcina, Tumor Microenvironment 2016	Hypoxia	iPOND	n/a	n/a
Raschle, Science 2015	Psoralen	Chromass-Label-free	42**	198***

^*These numbers included proteins that are at undamaged forks since the comparison was to a chase sample.

^**Additional samples were analyzed containing other inhibitors in addition to psoralen.

^***112 of these proteins were enriched in a replication-dependent manner.