Table 3.

Mortality in severe cutaneous adverse reactions related to targeted anticancer therapies and immunotherapies (n=14)

Agent	Phenotype	Age/sex	Underlying disease	Cause of death	Latency	Reference
Cetuximab	TEN	74/male	Adenocarcinoma of the sigmoid colon with hepatic metastasis	Pneumonia with renal/respiratory failure	14 days	6
Gefitinib	TEN	U/U	Non-small-cell lung cancer with leptomeningeal metastases	Systemic lung cancer progression	21 days	113
Imatinib	SJS	52/male	Chronic myeloid leukemia	Acute graft-versus-host disease of the gut	2 months	121
Bortezomib	TEN	61/male	IgG multiple myeloma	Multiorgan failure	4 days	131
Brentuximab vedotin	TEN	22/male	Anaplastic large-cell lymphoma, stage IIIA	Disease progression of lymphoma	20 days	138
Rituximab	SJS	36/male	Follicular non-Hodgkin’s lymphoma	Disease progression of lymphoma with inferior vena cava obstruction	5 months	134
Rituximab	SJS/TEN	78/male	Diffuse large B-cell lymphoma with bone marrow involvement	Died secondary to complications of SJS/TEN	U	63
Vemurafenib	TEN	69/male	Melanoma with axillary lymph nodes and pulmonary metastasis	Sepsis	4 days	139
Vemurafenib	TEN	63/female	Melanoma with cervical lymph-node, scalp, lung, and liver metastases	Disease progression of melanoma	3 months	68
Vemurafenib	TEN	73/female	Melanoma with inguinal lymph node metastasis	Multiple-organ failure after ventilator-acquired pneumonia and melena	35 days	142
Aldesleukin	TEN	67/female	Renal cell carcinoma with lung metastasis	Septic shock and hypovolemia secondary to pancytopenia and TEN	10 days	77
Denileukin	TEN	45/male	Follicular large-cell lymphoma with widespread lymphadenopathy, splenomegaly, and bone marrow involvement	Multisystem organ failure with massive TEN and disease progression of lymphoma	18 days	75
Nivolumab	TEN	64/female	Melanoma with pulmonary and liver metastases	Disease progression of melanoma and sepsis	4 months	79
Nivolumab	TEN	50/female	Metastatic malignant melanoma	Septic shock and multisystem organ failure	6 days	81

Abbreviations: SJS, Stevens–Johnson syndrome; TEN, toxic epidermal necrolysis; U, unknown.