Table 1.

Skeletal Phenotype of 12-Week-Old Mpl^f/f;PF4cre Female Mice

	μCT					Static histomorphometry
	Genotype	BV/TV	Tb.Th	Tb.N	Tb.Sp	N.Ob/mm	N.Oc/mm
Epiphysis	Mplf/f	17 ± 2	0.03 ± 0.001	5.8 ± 0.7	0.17 ± 0.03	10.0 ± 2.5	2.9 ± 0.3
	Mplf/f;PF4cre	20 ± 3	0.02 ± 0.003a	8.4 ± 1.8a	0.15 ± 0.02	5.8 ± 0.6a	1.9 ± 0.6a
Diaphysis	Mplf/f	0.02 ± 0.04	0.02 ± 0.01	0.03 ± 0.0	0.72 ± 0.04	N/D	N/D
	Mplf/f;PF4cre	25 ± 6a	0.03 ± 0.01a	4.6 ± 1.1a	0.10 ± 0.02a	12.0 ± 2.7	2.7 ± 0.8

μCT n = 6–8, static histomorphometry n = 3–5 mice. Results are presented as mean ± SEM. Significant difference compared to Mpl^f/f.

^ap < 0.05.

μCT, microcomputed tomography; BV/TV, bone volume/tissue volume; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness; N.Ob/mm, number of osteoblasts/mm; N.Oc/mm, osteoclast number/mm; SEM, standard error of the mean.