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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: J Surg Res. 2017 Mar 31;216:80–86. doi: 10.1016/j.jss.2017.03.025

Figure 1. ATP/P2X7R/p38 MAPK pathway antagonism restores contractility in a rat aorta (RA) subfailure overstretch injury model.

Figure 1

RA were untreated (Ctrl) or stretched to twice the ex vivo resting length (Stretch). The stretched segments were cut into 2mm rings and incubated for 1 hour in heparinized PlasmaLyte in the absence or presence of apyrase (Apy, 4 units/mL), the P2X7R inhibitor A438078 (A43, 100μM), or the p38 MAPK inhibitor SB203580 (SB, 20μM). Tissues were suspended on a muscle bath, contracted with phenylephrine (5×10−7M) and contractile responses were calculated (n=9–13, *p<0.05 compared to stretch injured tissue).