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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Pharmacol Ther. 2018 Feb 9;186:176–185. doi: 10.1016/j.pharmthera.2018.01.007

Figure 1. Model of Neurons and Glial Cells With Pathways of Thyroid Hormone Metabolism and Uptake.

Figure 1

Thyroid hormone action in the brain requires activation of thyroxine (T4) to the active triiodothyronine (T3), by the 5′-deiodinase 2 (Dio2), contained in glial cells. T3 uptake into neurons is mediated by specific transporters, Mct8 and Oatp1c1, present in both humans and mice, but humans appear most dependent on Mct8.