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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Pharmacol Ther. 2018 Feb 9;186:176–185. doi: 10.1016/j.pharmthera.2018.01.007

Table 1.

Thyroid signaling cross-talk with other pathways in models of neural development

Pathway/Nuclear Factor Process or Tissue Nature of Interaction Reference
Retinoic Acid Receptor Neural development Inhibits T3 action (Liu, et al., 2002)
Retinoic Acid Brain development Stimulates MCT8 expression and thyroid transport (Kogai, et al., 2010)
COUP-TF1 Expressed early in brain development Inhibits T3-induction of gene expression (Anderson, et al., 1998; Liu & Brent, 2002; Teng, et al., 2017)
SOX2 Promotes renewal of neural stem cells T3/THRA inhibits SOX2 expression (by downregulation of SSR1) and promotes differentiation (Lopez-Juarez, et al., 2012)
LXR Brain Cortical layering (Tan, et al., 2010)

COUP-TF1-Chicken Ovalbumin Upstream Transcription Factor 1, MCT8-monocarboxylate transporter 8, LXR-Liver X Receptor, Sox2-SRY (Sex Determining Region Y)-box2, SSR1-Sox 2 Regulatory Region 1