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Comparison IC50 Values (μM) for Fluorescein-Labeled Probe Displacement (100 nM) as Determined by Fluorescence Polarization to CBX1 (10 μM); CBX2 (1 μM); CBX4, CBX6, CBX7 (0.4 μM); and CBX8 (4 μM), n = 3.
| Compound | CBX Protein Chromodomain
|
|||||
|---|---|---|---|---|---|---|
| CBX1 | CBX2 | CBX4 | CBX6 | CBX7 | CBX8 | |
| PSL-28 | 9.5 | >100 | 9.6 | 7.5 | 49 | 14 |
| PSL-61 | 6.3 | 4.5 | 2.0 | 3.6 | 1.5 | 11 |
| PSL-81 | 58 | 7.3 | 32 | 8.1 | 4.3 | 29 |
