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Schematic representation of two representative nanoparticle-protein supramolecular architectures and their delivery mechanisms. Proteins non-covalently bound to nanoparticles are taken up by the cell via endocytosis, following endosomal release (a), while nanoparticle-protein nanocomposites are taken up by the cell via membrane fusion mechanism with direct release of the protein in the cytosol (b).
