Table 2.
Longitudinal changes in structural features of knees from baseline to follow-up measured by semi-quantitative magnetic resonance imaging Osteoarthritis Knee Score (MOAKS) grouped by weight loss at 1-year follow-up visit.
| Structural Feature | <20% Weight Loss at 1-Year1 [Mean (SD), Median] | ≥20% Weight Loss at 1-Year [Mean (SD), Median] | Coefficient for Mean Difference in Scores (95%CI) | |||
|---|---|---|---|---|---|---|
| Baseline | Follow-up | Baseline | Follow-up | Across Visits | Between Weight Loss Groups (<20% and ≥20%) | |
| Bone marrow lesion | ||||||
| Worst2 score | 1.14 (0.94), 1.00 | 1.26 (1.09), 2.00 | 1.10 (1.02), 1.00 | 1.15 (1.10), 1.00 | 0.04 (-0.12, 0.20) | 0.04 (-0.41, 0.50) |
| Sum3 of scores | 2.63 (2.84), 2.00 | 2.64 (2.88), 2.00 | 2.28 (2.47), 1.50 | 2.06 (2.30), 2.00 | -0.19 (-0.64, 0.25) | -0.16 (-1.27, 0.95) |
| Synovitis | ||||||
| Worst score | 0.89 (0.99), 1.00 | 0.85 (1.05), 0.50 | 0.79 (0.73), 1.00 | 0.80 (0.69), 1.00 | -0.03 (-0.15, 0.09) | -0.01 (-0.39, 0.38) |
| Sum of scores | 1.23 (1.44), 1.00 | 1.09 (1.38), 0.00 | 1.05 (1.22), 1.00 | 1.05 (0.99), 1.00 | -0.09 (-0.26, 0.08) | -0.02 (-0.58, 0.54) |
| Cartilage morphology | ||||||
| Worst score | 4.74 (1.93), 4.00 | 4.79 (1.82), 5.00 | 4.00 (2.28), 4.00 | 4.20 (2.31), 4.50 | 0.04 (-0.07, 0.15) | -0.37 (-1.33, 0.59) |
| Sum of scores | 16.83 (15.20), 12.00 | 16.11 (14.37), 13.00 | 16.13 (13.25), 13.50 | 16.88 (13.74), 14.00 | -0.84 (-2.51, 0.82) | 3.19 (-2.60, 8.97) |
2
Worst score is the maximum score across all sub-regions.
3
The scores sum is calculated using scores across all sub-regions.
CI - confidence interval, SD - standard deviation. The confidence intervals that included the null value of zero suggested lack of statistical significance.