Figure 2.
PD-1 KO LN-infused mice have increased T cell BM infiltration and antigen-specific T cell expansion. (A) Representative flow plots and statistical analyses of CD4+ and CD8+ T cells in the BM of PD-1 KO LN-infused mice. CD4+ and CD8+ T cells were gated on all live BM cells. (B) Representative flow plots and summarized results of H60-specific T cells in the BM of BM failure mice. H60 tetramer-positive cells were gated on live BM cells. (C) Representative flow plots and summarized results of H60-specific T cells in the spleens of BM failure mice. H60 tetramer-positive cells were gated on live splenocytes. Capped lines indicate a p-value obtained through unpaired t-test, while brackets indicate a p-value obtained through multiple comparisons. *, p < 0.05; **, p < 0.01.