Table 2.
Flow Cytometric Analysis of EC Surface Adhesion, Co-stimulatory, Co-inhibitory, and MHC-I Molecules at 24 Hours Postreperfusion.
| 24 HOURS POSTREPERFUSION | |||
|---|---|---|---|
| Molecule Name | Activated Cell Control (MFI) | Cold Ischemic Cells (MFI) | NIM811-Treated Cells (MFI) |
| VCAM-1 | 833.9 ±71.89 | 180.7 ±3.80 | 127.1 ±5.14 ** |
| ICAM-1 | 20.45 ±0.55 | 10.35 ±0.30 | 9.86 ±0.30 |
| E-selectin | 14.1 ±0.03 | 11.76 ±0.66 | 10.55 ±0.13 |
| PD-L1 | 30.82 ±0.36 | 12.44 ±0.06 | 12.27 ±0.12 |
| CD80 | 12.83 ±0.32 | 14.88 ±1.29 | 13.12 ±0.53 |
| CD86 | 5.46 ±0.03 | 5.00 ±0.02 | 4.93 ±0.08 |
| MHC I | 540 ±31.09 | 117.3 ±0.79 | 109.5 ±5.09 |
n=3, Cold Ischemic Cells vs NIM811-Treated Cells
p<0.005, Student t-test