Table 3.
Longitudinal change in mean T2 values in diabetics and non-diabetics.
| Absolute change in T2 values over 2 years
| ||||||
|---|---|---|---|---|---|---|
| Diabetics (n=151) | Non-diabetics (n=159) | |||||
|
|
||||||
| Adjusted means |
[95% CI] | Adjusted means |
[95% CI] | Effect size [95% CI]* | p-value | |
| Absolute change in mean T2 values | ||||||
|
| ||||||
| Global knee T2 | 1.77 | [1.51,2.03] | 0.98 | [0.68,1.28] | 0.79 [0.39,1.19] | <0.001 |
| PAT T2 | 1.33 | [0.82,1.84] | 1.38 | [0.87,1.89] | −0.05 [−0.79,0.68] | 0.885 |
| MT T2 | 1.85 | [1.50,2.20] | 1.27 | [0.90,1.64] | 0.58 [0.05,1.11] | 0.033 |
| LT T2 | 1.92 | [1.59,2.25] | 1.36 | [0.99,1.74] | 0.56 [0.04,1.07] | 0.034 |
| MF T2 | 1.08 | [0.76,1.40] | 0.52 | [0.14,0.91] | 0.56 [0.07,1.05] | 0.026 |
| LF T2 | 2.03 | [1.69,2.36] | 1.47 | [1.12,1.82] | 0.56 [0.09,1.03] | 0.020 |
|
| ||||||
| Absolute change in laminar (superficial) T2 values over 2 years | ||||||
|
| ||||||
| Global knee T2 | 1.82 | [1.51,2.13] | 1.37 | [1.02,1.71] | 0.45 [−.021,0.93] | 0.061 |
| PAT T2 | 1.41 | [0.81,2.00] | 1.65 | [0.96,2.34] | −0.24 [−1.15,0.66] | 0.592 |
| LT T2 | 2.27 | [1.85,2.69] | 1.62 | [1.14,2.10] | 0.65 [0.003,1.30] | 0.049 |
|
| ||||||
| Absolute change in laminar (bone) T2 values over 2 years | ||||||
|
| ||||||
| Global knee T2 | 1.51 | [1.28,1.75] | 0.98 | [0.71,1.25] | 0.53 [0.15,0.91] | 0.006 |
| PAT T2 | 1.21 | [0.73,1.69] | 1.21 | [0.78,1.64] | 0.004 [−0.63,0.64] | 0.991 |
| LT T2 | 1.31 | [0.97,1.65] | 1.06 | [0.73,1.38] | 0.25 [−0.22,0.73] | 0.292 |
|
| ||||||
| Absolute change in texture parameters | ||||||
|
| ||||||
| Global knee contrast | 93.75 | [73.01,114.48] | 56.09 | [38.09,74.08] | 37.66 [9.77,65.56] | 0.009 |
| PAT contrast | 78.25 | [59.30,97.20] | 53.89 | [33.11,74.66] | 24.36 [−05.79,54.51] | 0.112 |
| LT contrast | 44.72 | [28.02,61.41] | 32.42 | [20.37,44.46] | 12.30 [−9.06,33.66] | 0.256 |
|
| ||||||
| Global knee variance | 44.50 | [34.35,54.65] | 35.18 | [25.81,44.55] | 9.32[−4.69,23.32] | 0.190 |
| PAT variance | 35.21 | [24.13,46.30] | 33.88 | [22.28,45.48] | 1.33 [−15.06,17.73] | 0.872 |
| LT variance | 24.70 | [15.39,34.01] | 25.70 | [17.74,33.66] | −1.00[−13.12,11.12] | 0.870 |
|
| ||||||
| Global knee entropy | 0.01 | [−0.02.0.04] | 0.04 | [0.01,0.07] | −0.03 [−0.07,0.02] | 0.255 |
| PAT entropy | −0.04 | [−0.09,0.01] | −0.08 | [−0.14,−0.03] | 0.04 [−0.03,0.12] | 0.260 |
| LT entropy | 0.12 | [0.07,0.17] | 0.12 | [0.07,0.18] | −0.002 [−0.09,0.08] | 0.954 |
Data are given as adjusted means, corrected for race, age, sex, baseline BMI, baseline KL score, with [95% confidence intervals] and computed as the absolute change between the 24-months and the baseline.
*
Effect size for difference in T2 and texture parameters between groups; P-values <0.05 are in bold with the significant higher mean T2 value in underlined characters. PAT = patella, MT = medial tibia, LT = lateral tibia, MF = medial femur, LF = lateral femur.