Table 2.
Description of reactions
| Characteristic | Result (n = 6455) |
|---|---|
| Any anaphylactoid reaction (%) | 528 (8.2) |
| Type of reaction (%): | |
| Cutaneous only | 398 (6.2) |
| Systemic only | 34 (0.5) |
| Both cutaneous and systemic | 96 (1.5) |
| NAC dosing phase in progress at reaction onset (%): | |
| First (150 mg/kg 15–60 min) | 133 (2.1) |
| Second (50 mg/kg over 4 h) | 371 (5.7) |
| Third (100 mg/kg over 16 h) | 24 (0.4) |
| Duration of first (loading) phase in patients experiencing reaction during this phase (%): | |
| 15 min | 75 (1.1) |
| 30 min | 26 (0.4) |
| > 30 min | 32 (0.5) |
| NAC infusion interrupted or discontinued | 274 (4.2) |
| Medications administered for anaphylactoid reaction (%): | |
| Antihistamines | 371 (5.7) |
| β2-agonists | 15 (0.2) |
| Epinephrine | 10 (0.2) |
| Corticosteroids | 7 (0.1) |
| Any medication | 403 (6.2) |
NAC N-acetylcysteine, IQR interquartile range