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. 2018 May 21;8:7937. doi: 10.1038/s41598-018-25754-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment analysis of the PD-GRN genes and visualization of five network modules corresponding to PD-related GO terms. Five GO terms are often affected in PD cases. The total list of the enriched GO terms is found in Table S2. The central scatter plot shows the visualization of the top enriched generic GO terms of the PD-GRN in a two dimensional space based on the GO semantic similarities. GO term node colours indicate the p-values for the enrichment of the GO terms. These generic GO terms represent implicitly their subterms, which are not visualized in the plot. The scatter plot was generated using the web tool REVIGO⁷⁹. All five network modules include both miRNAs and genes. The main TF CEBPB is highlighted by a cyan triangle while the miRNAs are represented by orange squares. The genes co-targeted by TFs and/or miRNAs are depicted in larger pink circles. The regulated genes, regulated by a TF or by a miRNA, are coloured in grey. The network modules were visualized using the Cytoscape tool.