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. 2018 May 21;8:7899. doi: 10.1038/s41598-018-26237-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Schematic representation of the design of the experimental study. (B) Schematic representation of data analyzed by the SOMAscan proteomic assay. (C) Color map of relative fluorescence units (RFU) of the 738 proteins that were significantly altered after the ischemia. Squares are color coded; bright yellow color indicates high RFU and pale orange color indicate low RFU. The brighter the color is, the higher RFUs are. A1-A6 indicate samples obtained before MCAO; B1-B6 indicate samples obtained 2 h after MCAO; C1-C6 indicate samples obtained before sham surgery; D1-D6 indicate samples obtained after sham surgery. Abbreviations: CSF: cerebrospinal fluid; MCAO: middle cerebral artery occlusion.