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. 2018 Mar 3;92(5):1729–1739. doi: 10.1007/s00204-018-2181-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Schematic model of how PFOA may promote cell cycle progression, stimulate cell proliferation and transformation in MCF-10A cells. PFOA acts through PPARα, up-regulating cyclin D1 and CDK4/6 and down-regulating p27, to drive cells into the cell cycle from G₁ to S, and promote cell cycle progression