Table 3.
Effect of HF and GL on MDA, NP-SH and Total protein in liver and Kidney tissues.
| Treatment | Dose (mg/kg) | MDA (nmol/g) |
NP-SH (nmol/g) |
Total protein (g/l) |
|||
|---|---|---|---|---|---|---|---|
| Liver | Kidney | Liver | Kidney | Liver | Kidney | ||
| Control | – | 0.36 ± 0.02 | 0.29 ± 0.03 | 6.75 ± 0.40 | 4.58 ± 0.25 | 105.38 ± 3.76 | 150.44 ± 2.82 |
| CCl4a | 1.25 mL/kg | 4.79 ± 0.18*** | 3.92 ± 0.24*** | 2.76 ± 0.33*** | 2.71 ± 0.15*** | 52.68 ± 2.31*** | 70.25 ± 4.81*** |
| SI + CCl4b | 10 | 0.92 ± 0.07*** | 1.00 ± 0.06*** | 4.24 ± 0.21** | 4.41 ± 0.21*** | 97.40 ± 3.74*** | 119.35 ± 2.58*** |
| HFb | 12 | 4.02 ± 0.29* | 3.09 ± 0.09* | 2.68 ± 0.30 | 2.87 ± 0.15 | 56.28 ± 1.83 | 80.23 ± 3.84 |
| GLb | 84 | 4.17 ± 0.36 | 2.79 ± 0.14** | 2.94 ± 0.26 | 3.24 ± 0.22 | 55.08 ± 2.31 | 83.82 ± 2.62* |
| HF + GLb | 6 + 42 | 2.79 ± 0.17*** | 2.10 ± 0.11*** | 3.96 ± 0.36* | 3.45 ± 0.14** | 65.86 ± 2.81** | 96.20 ± 3.11*** |
| HF + GLb | 12 + 84 | 2.07 ± 0.13*** | 1.52 ± 0.09*** | 4.18 ± 0.22** | 3.47 ± 0.11** | 72.65 ± 2.36*** | 110.97 ± 3.19*** |
All values represent mean ± SEM of n = 5.
NP-SH: Non-protein sulfhydryl groups; MDA: malondialdehyde.
a
As compared with Control group (administered with a solution of 0.9% sodium chloride).
b
As compared with CCl4 only group.
*
p < .05;
**
p < .01;
***
p < .001; ANOVA, followed by Dunnett's multiple comparison test.