Table 1.

Tissue-level parameter search space.

Parameter	Multiplier
nbac: initial number of bacteria	[10,100] times
nmac: initial number of macrophages	[1,5] times
difk: diffusion constant of chemokines	[0.1,10] times
antg: number of antigens recognized per bacterium	[0.1,10] times
srfm: movement speed of bacteria on the surface	[0.1,10] times
flom: movement of bacteria in lining fluid	[0.1,10] times
radm: movement of lining fluid	[0.1,10] times
doub: doubling time of bacteria	[0.1,10] times
dwel: probability that bacteria will remain in the same phase	[0.991,1.001] times
satr: saturation of bacterial growth	[0.1,10] times
caps: kinetic constant for capsule production	[0,2] times
macm: macrophage movement speed	[0.1,10] times
phag: phagocytosis rate	[0.1,10] times
maxb: maximum bacteria per phagocytosis	[0.1,2] times
lpss: LPS sensitivity of macrophages	[0.1,10] times
cytg: MCP-1 sensitivity of macrophages	[0.1,10] times
All intracellular parameters (for details see Supp. Mat.)	[0.5,2] times

The range is generated around the nominal value (see Supplementary Material, Table S1), with the exception of the number of bacteria and macrophages (nbac and nmac), and is represented as the factors by which the nominal value is multiplied. Note that the explanation for the intracellular-level parameters is given in Supplementary Material.