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. 2018 May 15;9:481. doi: 10.3389/fphar.2018.00481

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Copyright © 2018 Saeed, Mahmoud, Sugimoto, Efferth and Abdel-Aziz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose response curves of BetA. (A) Cytotoxicity of BetA toward drug-sensitive parental CCRF-CEM tumor cells and their P-glycoprotein (MDR1/ABCB1)-expressing, multidrug-resistant subline, CEM/ADR5000. (B) Cytotoxicity of BetA toward MDA-MB-231-pc DNA cells and their BCRP-transduced subline, MDA-MB-231-BCRP as determined by resazurin assays. (C) Cytotoxicity of BetA toward HEK293 cells and their ABCB5-transfectant subline, HEK293/ABCB5 as determined by resazurin assays. (D) Cytotoxicity of BetA U87MG cells and their EGFR- transduced subline U87MGΔEGFR, as determined by resazurin assays.