Figure 5.

Molecular docking for BetA to AMFR (Autocrine Motility Factor Receptor) and its ligand AMF. (A) Schematic aligning structure of AMFR transmembrane domains at the N-terminal and cytosolic domains at C-terminal tail. (B) CUE domain functions to help substrate binding for ubiquitination. (C) E2 ubiquitin-conjugating enzyme binding domain. (D) p97/VCP binding domain that participates in the final step of endoplasmic reticulum-associated degradation. (E) Autocrine Motility factor ligand. The proteins were depicted in a new carton format, whereas BetA was represented in dynamic bond format with red color.