Table 2.

Correlation of constitutive mRNA expression of genes identified by COMPARE analysis with log₁₀IC₅₀ values for BetA of the NCI tumor cell lines.

COMPARE coefficient	Experiment ID	Gene symbol	Name	Function
0.497	GC28294	CHEK2	CHK2 checkpoint homolog (S. pombe) RNA	Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B, and CDC25C, inhibiting their activity.
0.428	GC33596	CDC25C	Cell division cycle 25 homolog C (S. pombe) RNA	This gene encodes a conserved protein that plays a key role in the regulation of cell division.
0.425	GC29591	FBL	Fibrillarin RNA	Also acts as a protein methyltransferase by mediating methylation of Gln-105 of histone H2A (H2AQ104me).
0.424	GC30713	NVL	Nuclear VCP-like RNA	May play a role in 60S ribosomal subunit biogenesis.
0.411	GC35294	TPM2	Tropomyosin 2 (beta) RNA	Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.
0.405	GC37151	CCDC9	Coiled-coil domain containing 9 RNA	Not available
0.403	GC39011	LIN37	Lin-37 homolog (C. elegans) RNA	Not available
0.391	GC27490	ADAM3A	ADAM metallopeptidase domain 3A RNA	Anchored cell surface adhesion protein.
0.389	GC37907	KIFC1	Kinesin family member C1 RNA	Minus end-directed microtubule-dependent motor required for bipolar spindle formation.
0.387	GC31813	LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) RNA	May be involved in pre-mRNA splicing.
0.386	GC29011	FAM50A	Family with sequence similarity 50, member A RNA	May be a DNA-binding protein or transcriptional factor.
0.384	GC28346	DNTTIP2	Deoxynucleotidyltransferase, terminal, interacting protein 2 RNA	May function as a chromatin remodeling protein.
0.384	GC31325	LAGE3	L antigen family, member 3 RNA	The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.
0.382	GC31480	WDR67	WD repeat domain 67 RNA	Not available
0.379	GC39257	CBX5	Chromobox homolog 5 RNA	Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression.
0.378	GC33227	PTP4A2	Protein tyrosine phosphatase type IVA, member 2 RNA	Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis.
0.377	GC39416	LY6H	Lymphocyte antigen 6 complex, locus H RNA	May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface.
0.375	GC27749	CKS1B	CDC28 protein kinase regulatory subunit 1B RNA	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
0.375	GC38283	GNG5	Guanine nucleotide binding protein (G protein), gamma 5 RNA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.
0.372	GC31629	CCBL2	Cysteine conjugate-beta lyase 2 RNA	Not available
−0.452	GC30666	IQCK	IQ motif containing K RNA	Not available
−0.417	GC27424	LITAF	Lipopolysaccharide-induced TNF factor RNA	EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades.
−0.4	GC28487	GNG12	Guanine nucleotide binding protein (G protein), gamma 12 RNA	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems.
−0.397	GC35009	AP3S2	Adaptor-related protein complex 3, sigma 2 subunit RNA	It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
−0.389	GC30667	IQCK	IQ motif containing K RNA	Not available
−0.387	GC29994	GRIK2	Glutamate receptor, ionotropic, kainate 2 RNA	L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
−0.383	GC29004	CEP170B	Centrosomal Protein 170B	Plays a role in microtubule organization.
−0.381	GC29545	PPP2R4	Protein phosphatase 2A activator, regulatory subunit 4 RNA	Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A.
−0.378	GC31014	PTPRJ	Protein tyrosine phosphatase, receptor type, J RNA	Plays a role in cell adhesion, migration, proliferation and differentiation.
−0.378	GC37170	PKD2	Polycystic kidney disease 2 (autosomal dominant) RNA	Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium.
−0.374	GC38895	ZNF652	Zinc finger protein 652 RNA	Functions as a transcriptional repressor.
−0.372	GC28476	AMFR	Autocrine motility factor receptor RNA	E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation.
−0.368	GC34353	ERN1	Endoplasmic reticulum to nucleus signaling 1 RNA	This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR).
−0.364	GC32085	SASH1	SAM and SH3 domain containing 1 RNA	May have a role in a signaling pathway. Could act as a tumor suppressor.
−0.354	GC37023	CLCN5	Chloride channel 5 RNA	May play an important role in renal tubular function.
−0.354	GC29372	NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase RNA	Catalyzes the second step in the formation of the mannose 6-phosphate.
−0.354	GC33773	ERBB3	V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) RNA	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins.
−0.352	GC36873	WWTR1	WW domain containing transcription regulator 1 RNA	plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
−0.351	GC27626	KANK1	KN motif and ankyrin repeat domains 1 RNA	Involved in the control of cytoskeleton formation by regulating actin polymerization.
−0.351	GC35063	SLC22A5	Solute carrier family 22 (organic cation/carnitine transporter), member 5 RNA	The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine.