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. 2018 May 15;9:529. doi: 10.3389/fphys.2018.00529

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Copyright © 2018 Wang, Wang, Chen, Zhao and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Xinnao shutong (XNST) ameliorates cognitive function following chronic cerebral hypoperfusion. (A) Comparisons of weight for each group on day 0, 3, 7, 14, 28, and 42. (B) The escape latency of rats in the training trials of the hidden platform task. (C) Representative pathways for the first and last training day of the hidden platform task for each group. (D) Frequency of platform crossing in the probe trial. (E) Percentage of time spent in the target quadrant in the probe trial. (F) Swimming speed in the probe trial. Values are expressed as mean ± SEM (n = 12). ^∗p < 0.05 vs. Sham, ^∗∗p < 0.01 vs. Sham, ^#p < 0.05 vs. Model, ^##p < 0.01 vs. Model.