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. 2018 May 15;9:472. doi: 10.3389/fphys.2018.00472

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Copyright © 2018 Platt, Huber, Romanova, Brunt and Simpson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation plots between measures of body growth and cardiac growth in sham mice between 9 and 27 weeks of age (n = 40). (A) Heart weight/body weight (HW/BW) plotted against body weight. (B) Heart weight/tibial length (HW/TL) plotted against tibial length. The lack of slope in (B) indicates HW/TL is less impacted by growth (i.e., changes in the denominator) than HW/BW. This suggests that normalizing cardiac weight to TL is a better method for determining cardiac hypertrophy between groups of varying weight/age.