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. 2018 May 15;9:472. doi: 10.3389/fphys.2018.00472

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Copyright © 2018 Platt, Huber, Romanova, Brunt and Simpson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chamber size and echocardiographic function over 18 weeks of TAC. (A) Representative M-mode images acquired from the mid-papillary region of the LV. (B) Left ventricular end diastolic (EDD) and end systolic (ESD) dimensions, (C) cardiac output and (D) ejection fraction demonstrate dilation and a decline in cardiac function, especially between the 9 and 18 week time-points. Heart rate was statistically unchanged between all time points. ^∗p < 0.01 vs. age-matched sham. ^†p < 0.01 vs. previous time point.