Table 1.
Invasive hemodynamics from the left and right ventricles in TAC.
| TAC | |||||
|---|---|---|---|---|---|
| Left Ventricle (LV) | Pre Surgery (n = 9) | 2 weeks (n = 24) | 4 weeks (n = 16) | 9 weeks (n = 16) | 18 weeks (n = 22) |
| LVP (mmHg) | 95 ± 2 | 144 ± 3∗,† | 169 ± 4∗,† | 146 ± 3∗,† | 118 ± 5† |
| EDP (mmHg) | 4.6 ± 1.4 | 20.2 ± 1.2∗,† | 21.7 ± 2.4∗ | 17.2 ± 2.8∗ | 22.3 ± 1.1∗ |
| LV min Pressure (mmHg) | -2.8 ± 0.9 | 9.0 ± 1.0∗,† | 7.1 ± 1.6∗ | 7.5 ± 2.1∗ | 13.1 ± 1.2∗,† |
| Systolic Pressure (mmHg) | 88 ± 3 | 142 ± 2∗,† | 163 ± 5∗,† | 144 ± 3∗,† | 118 ± 4† |
| Diastolic Pressure (mmHg) | 61 ± 3 | 65 ± 2 | 61 ± 3∗ | 57 ± 3∗ | 57 ± 3∗ |
| dP/dtmax (mmHg/s) | 9838 ± 388 | 7685 ± 191∗,† | 9552 ± 391† | 8259 ± 486† | 6148 ± 332∗,† |
| dP/dt@LVP40(mmHg/s) | 9314 ± 401 | 7116 ± 229∗,† | 8755 ± 441† | 7512 ± 529 | 5655 ± 274∗,† |
| dP/dtmin (mmHg/s) | -9861 ± 464 | -7762 ± 205∗,† | -9684 ± 464† | -8502 ± 519 | -5661 ± 373∗,† |
| Tau (Weiss, ms) | 6.54 ± 0.31 | 7.5 ± 0.18 | 6.65 ± 0.35† | 6.97 ± 0.42 | 10.39 ± 0.96∗,† |
| Tau (Glantz, ms) | 7.41 ± 0.55 | 11.78 ± 0.30∗,† | 10.36 ± 0.57† | 10.98 ± 0.70 | 15.33 ± 0.51∗,† |
| Tau (Logistics, ms) | 8.27 ± 0.62 | 13.46 ± 0.41∗,† | 11.98 ± 0.67 | 12.66 ± 0.84 | 17.58 ± 0.58∗,† |
| Tau (Mirsky, ms) | 4.35 ± 0.19 | 5.25 ± 0.08∗,† | 4.76 ± 0.17† | 4.86 ± 0.17 | 6.04 ± 0.21† |
| HR (bpm) | 573 ± 18 | 595 ± 9 | 599 ± 18 | 588 ± 12 | 574 ± 11 |
| Right Ventricle (RV) | Pre Surgery (n = 5) | 2 weeks (n = 9) | 4 weeks (n = 10) | 9 weeks (n = 11) | 18 weeks (n = 10) |
| RVP (mmHg) | 27 ± 1 | 32 ± 1∗,† | 52 ± 4∗,† | 39 ± 2∗,† | 39 ± 2∗ |
| EDP (mmHg) | 1.4 ± 0.5 | 2.4 ± 0.5 | 9.7 ± 1.6∗,† | 5.0 ± 0.7∗,† | 5.8 ± 1.0∗ |
| RV min Pressure (mmHg) | 0.3 ± 0.3 | 0.5 ± 0.5 | 6.2 ± 1.4∗,† | 1.8 ± 0.9† | 3.0 ± 0.8∗ |
| dP/dtmax (mmHg/s) | 2138 ± 177 | 2088 ± 40 | 2853 ± 255† | 2362 ± 80∗,† | 2021 ± 95∗,† |
| dP/dtmin (mmHg/s) | -1923 ± 147 | -1969 ± 73 | -2616 ± 132∗,† | -2294 ± 72† | -1944 ± 93∗,† |
| Tau (Weiss, ms) | 5.83 ± 0.54 | 6.84 ± 0.72 | 9.77 ± 0.92∗,† | 8.95 ± 0.41∗ | 11.56 ± 1.42∗ |
| Tau (Glantz, ms) | 8.47 ± 1.03 | 11.97 ± 0.59∗,† | 13.81 ± 1.00∗ | 13.24 ± 0.73∗ | 15.18 ± 2.07∗ |
LVP, left ventricular pressure; EDP, end diastolic pressure; HR, heart rate; RVP, right ventricular pressure. Values are mean ± SEM. ∗p < 0.05 vs. age-matched sham. †p < 0.05 vs. previous time point. Bolded numbers draw attention to significance vs. age-matched sham.