Table 3.
Morphometric characteristics of TAC mice.
| TAC | |||||
|---|---|---|---|---|---|
| Variable | Pre-surgery (n = 11) | 2 weeks (n = 16) | 4 weeks (n = 16) | 9 weeks (n = 15) | 18 weeks (n = 14) |
| BW (g) | 37.2 ± 0.7 | 38.3 ± 2.9∗ | 40.8 ± 3.1∗,† | 45.2 ± 7.2∗,† | 44.1 ± 7.1∗ |
| TL (cm) | 1.84 ± 0.02 | 1.84 ± 0.04 | 1.87 ± 0.03† | 1.90 ± 0.03 | 1.93 ± 0.03† |
| Heart Weight (mg) | 152 ± 4 | 200 ± 24∗,† | 235 ± 30∗,† | 270 ± 40∗,† | 312 ± 59∗,† |
| Atria Weight (mg) | 9 ± 1 | 16 ± 6∗,† | 20 ± 7∗,† | 25 ± 12∗,† | 36 ± 18∗,† |
| LV Weight (mg) | 79 ± 3 | 98 ± 8∗,† | 112 ± 24∗ | 128 ± 17∗ | 158 ± 16∗,† |
| LV CSA (μm2) | 189 ± 15 | 296 ± 19∗,† | 373 ± 44∗,† | 471 ± 52∗,† | 658 ± 87∗,† |
| RV Weight (mg) | 35 ± 2 | 36 ± 5 | 45 ± 9∗,† | 54 ± 13∗,† | 59 ± 11∗ |
| RV CSA (μm2) | 150 ± 14 | 168 ± 9 | 234 ±14∗ | 237 ± 12∗ | 241 ± 17∗ |
| Septum Weight (mg) | 37 ± 3 | 49 ± 7∗,† | 57 ± 10∗,† | 60 ± 5∗ | 66 ± 9∗ |
| Lung Wet Weight (mg) | 221 ± 12 | 230 ± 49 | 273 ± 73† | 349 ± 152∗ | 450 ± 187∗ |
| Lung Wet/Dry Ratio | 4.23 ± 0.09 | 4.26 ± 0.86 | 4.34 ± 0.58 | 4.30 ± 0.67 | 4.23 ± 0.94 |
| Kidney Weight avg (mg) | 269 ± 10 | 269 ± 37∗ | 272 ± 39∗ | 295 ± 42 | 316 ± 72 |
| Spleen Weight (mg) | 97 ± 6 | 139 ± 27∗,† | 113 ± 15† | 128 ± 28 | 171 ± 35∗,† |
| Liver Weight (g) | 1.68 ± 0.14 | 1.87 ± 0.13 | 1.89 ± 0.32 | 2.08 ± 0.44 | 2.07 ± 0.24∗ |
BW, body weight; TL, tibial length; LV, left ventricle; RV, right ventricle; Values are mean ± SD. ∗p < 0.05 vs. age-matched sham. †p < 0.05 vs. previous time point. Bolded numbers draw attention to significance vs. age-matched sham.