Table 4.
Morphometric characteristics of sham mice.
| sham | |||||
|---|---|---|---|---|---|
| Variable | Pre-surgery (n = 11) | 2 weeks (n = 8) | 4 weeks (n = 10) | 9 weeks (n = 9) | 18 weeks (n = 10) |
| BW (g) | 37.2 ± 2.3 | 40.4 ± 3.1∗,† | 44.0 ± 4.2∗,† | 51.0 ± 7.0∗,† | 55.1 ± 10.0∗,† |
| TL (cm) | 1.84 ± 0.05 | 1.85 ± 0.03 | 1.88 ± 0.03∗,† | 1.91 ± 0.02∗,† | 1.92 ± 0.04∗ |
| Heart Weight (mg) | 158 ± 14 | 171 ± 10∗,† | 181 ± 9∗ | 191 ± 14∗,† | 200 ± 16∗ |
| Atria Weight (mg) | 9 ± 2 | 10 ± 2 | 11 ± 1 | 11 ± 1 | 12 ± 3∗ |
| LV Weight (mg) | 79 ± 7 | 83 ± 10 | 85 ± 9 | 88 ± 8 | 91 ± 3∗ |
| LV CSA (μm2) (n = 4) | 189 ± 15 | 191 ± 11 | 196 ± 13 | 209 ± 12 | 213 ± 13 |
| RV Weight (mg) | 33 ± 5 | 37 ± 6 | 41 ± 2∗ | 44 ± 3∗ | 45 ± 2∗ |
| RV CSA (μm2) (n = 4) | 150 ± 9 | 154 ± 10 | 160 ± 11 | 166 ± 10 | 171 ± 12 |
| Septum Weight (mg) | 37 ± 6 | 41 ± 7 | 44 ± 8 | 48 ± 8∗ | 52 ± 7∗ |
| Lung Wet Weight (mg) | 221 ± 28 | 235 ± 32 | 252 ± 17 | 238 ± 44 | 235 ± 48 |
| Lung Wet/Dry Ratio | 4.23 ± 0.23 | 4.25 ± 0.71 | 4.51 ± 0.16 | 4.30 ± 0.42 | 4.49 ± 0.70 |
| Kidney Weight avg (mg) | 269 ± 24 | 305 ± 23∗,† | 318 ± 18∗ | 335 ± 30∗ | 342 ± 31∗ |
| Spleen Weight (mg) | 97 ± 14 | 112 ± 16∗,† | 107 ± 15 | 115 ± 9∗ | 133 ± 7∗,† |
| Liver Weight (g) | 1.68 ± 0.34 | 1.99 ± 0.16 | 2.10 ± 0.29∗ | 2.24 ± 0.36∗ | 3.01 ± 0.65∗,† |
BW, body weight; TL, tibial length; LV, left ventricle; RV, right ventricle; Values are mean ± SD. ∗p < 0.05 vs. pre-surgery values. †p < 0.05 vs. previous time point. Bolded numbers draw attention to significance vs. pre-surgery values.