Table 5.
Expanded echocardiographic function.
| TAC | |||||
|---|---|---|---|---|---|
| Variable | Pre-surgery (n = 8) | 2 weeks (n = 15) | 4 weeks (n = 12) | 9 weeks (n = 17) | 18 weeks (n = 13) |
| DimensionDiastole (mm) | 4.38 ± 0.04 | 4.39 ± 0.04 | 4.66 ± 0.07∗,† | 4.78 ± 0.07∗ | 5.11 ± 0.09∗,† |
| DimensionSystole (mm) | 2.95 ± 0.01 | 3.43 ± 0.05∗,† | 3.74 ± 0.08∗,† | 3.86 ± 0.12∗ | 4.49 ± 0.13∗,† |
| VolumeDiastole (μL) | 86.9 ± 1.8 | 87.1 ± 1.8 | 100.9 ± 3.3∗,† | 107.2 ± 3.8∗ | 124.9 ± 4.9∗,† |
| VolumeSystole (μL) | 33.5 ± 0.4 | 48.6 ± 1.6∗,† | 60.0 ± 3.1∗,† | 65.6 ± 4.9∗ | 93.4 ± 5.9∗,† |
| Stroke Volume (μL) | 53.4 ± 1.6 | 38.5 ± 1.3∗,† | 40.8 ± 2.3∗ | 41.6 ± 1.6∗ | 31.5 ± 2.0∗,† |
| Ejection Fraction (%) | 61.3 ± 0.7 | 44.3 ± 1.2∗,† | 40.6 ± 2.1∗ | 39.9 ± 2.4∗ | 26.1 ± 2.2∗,† |
| Fractional Shortening (%) | 32.7 ± 0.5 | 21.8 ± 0.8∗,† | 19.9 ± 1.1∗ | 19.6 ± 1.3∗ | 12.3 ± 1.1∗,† |
| Cardiac Output (mL/min) | 29.1 ± 0.5 | 21.9 ± 0.7∗,† | 23.6 ± 1.3∗ | 22.8 ± 0.8∗ | 22.8 ± 0.8∗,† |
| Wall ThicknessDiastole (mm) | 0.88 ± 0.02 | 1.15 ± 0.01∗,† | 1.20 ± 0.01∗,† | 1.23 ± 0.01∗ | 1.30 ± 0.02∗,† |
| Heart Rate (bpm) | 548 ± 10 | 570 ± 7 | 578 ± 13 | 557 ± 6 | 575 ± 11∗ |
| sham | |||||
| Variable | Pre-surgery (n = 8) | 2 weeks (n = 8) | 4 weeks (n = 8) | 9weeks (n = 9) | 18 weeks (n = 12) |
| DimensionDiastole (mm) | 4.38 ± 0.04 | 4.39 ± 0.04 | 4.44 ± 0.04 | 4.50 ± 0.07 | 4.62 ± 0.04# |
| DimensionSystole (mm) | 2.95 ± 0.01 | 2.99 ± 0.04 | 3.05 ± 0.06 | 3.05 ± 0.08 | 3.19 ± 0.06# |
| VolumeDiastole (μL) | 86.9 ± 1.8 | 87.5 ± 1.9 | 89.5 ± 1.9 | 92.6 ± 3.7 | 98.6 ± 1.8# |
| VolumeSystole (μL) | 33.5 ± 0.4 | 34.8 ± 1.2 | 36.6 ± 1.7 | 36.8 ± 2.5 | 41.0 ± 1.8# |
| Stroke Volume (μL) | 53.4 ± 1.6 | 52.7 ± 1.0 | 52.9 ± 1.2 | 55.8 ± 1.4 | 57.7 ± 0.9# |
| Ejection Fraction (%) | 61.3 ± 0.7 | 60.3 ± 0.7 | 59.1 ± 1.4 | 60.6 ± 1.2 | 58.7 ± 1.2 |
| Fractional Shortening (%) | 32.7 ± 0.5 | 32.0 ± 0.5 | 31.2 ± 0.7 | 32.3 ± 0.8 | 31.0 ± 0.8 |
| Cardiac Output (mL/min) | 29.1 ± 0.5 | 29.2 ± 0.6 | 29.2 ± 0.6 | 30.3 ± 0.8 | 30.8 ± 0.3# |
| Wall ThicknessDiastole (mm) | 0.88 ± 0.02 | 0.92 ± 0.03 | 0.94 ± 0.03# | 0.97 ± 0.03# | 0.99 ± 0.04# |
| Heart Rate (bpm) | 548 ± 10 | 554 ± 7 | 552 ± 11 | 544 ± 8 | 535 ± 7 |
∗p < 0.05 vs. age-matched sham mice. †p < 0.05 vs. previous time point. #p < 0.05 in sham vs. pre-surgery time point. Bolded values draw attention to significance vs. age-matched sham (top) and to significance vs. pre-surgery values (bottom).