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. 2018 May 15;9:497. doi: 10.3389/fphar.2018.00497

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Copyright © 2018 Wu, Li, Cui, Wu, Hong, Li, Wu, Jie, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nrf2 activation induced by acacetin is mediated by AMPK. (A) Western blots and relative level of pAMPK in H9C2 cardiomyoblasts treated by 0.3, 1, or 3 μM acacetin. (B) Western blots and relative level of Nrf2 in H9C2 cardiomyoblasts transfected with control siRNA or AMPK siRNA in the absence or presence of 3 μM acacetin. (C) Western blots and relative level of Nrf2 in left ventricular tissues of rats subjected to ischemia/reperfusion injury with treatment of acacetin or Compound C plus acacetin. Data were expressed as mean ± SEM and analyzed by one-way ANOVA followed by Bonferroni-test (n = 5 individual experiments, ^∗P < 0.05 vs. sham, ^∗∗P < 0.01 vs. control or vehicle of control siRNA or sham; ^#P < 0.05 vs. acacetin; ^##P < 0.01 vs. control siRNA with acacetin).