FIGURE 2.

Dasatinib-induced changes in endothelial TEER (A) and permeability (B) are concentration-dependent. HMVEC-L and HPAEC cells were exposed to dasatinib (das: 1 nM, 10 nM, or 100 nM) or vehicle (ctrl: 0.1% DMSO) for 24 h. Two-way ANOVA test was performed with Tukey post hoc multiple comparison test. Values are presented as mean ± SD; ^∗p < 0.05, ^‡p < 0.01, ⁺p < 0.001, ^∙p < 0.0001 compared to ctrl. Representative results of three independent experiments (N = 3) are shown.