Table 4.

Treatment of OPC (Vazquez, 2010; Lortholary et al., 2012; Patil et al., 2015).

Anti–fungal agents		Form	Dosage
First line	Nystatin Clotrimazole Miconazole Fluconazole	Suspension (100,000 U/mL) Pastilles (200,000 U each) Oral troche (10 mg) Lauriad Muco-adhesive buccal Tablets (50 mg) Tablet (100 mg−200 mg) Solution (10 mg/mL) (PO or I.V.)	4–6 mL four times daily for 7–14 days 1–2 mL four times daily for 7–14 days 1 five times daily for 7–14 days Once daily for 7–14 days Once daily for 7–14 days (Apply to mucosal surface following detailed manufacturer instructions) 1 tablet daily for 7–14 days 10 mL once daily for 7–14 days
Second line	Itraconazole Posaconazole Voriconazole	Capsule (200 mg) (PO) Solution (10 mg/mL) (PO) Tablet (400 mg) (PO) Tablet (200 mg) (PO or I.V.)	1 capsule daily for 28 days 10–20 mL once daily Daily in divided doses 2 tablets daily
Refractory cases	Caspofungin Micafungin Anidulafungin Amphotericin B Amphotericin B deoxycholate	I.V. I.V. I.V. Oral suspension I.V.	70 mg (loading dose) followed by 50 mg daily 100–150 mg daily 100 mg (loading dose) followed by 50 mg daily 500 mg every 6 h. 0.3 mg/kg once