FIGURE 2.

Continuous TBS to premotor cortex increases BOLD responses in frontoparietal cortices compared to vertex stimulation. In order to look at the effect of cTBS to right premotor cortex on perception of sounds, compared to stimulation at the vertex, individual t-tests for the comparison of each condition post-stimulation > pre-stimulation were calculated. These t-tests, which reflect the difference between pre- and post-stimulation were then entered into a 2 × 6 ANOVA, whereby the two factors were ‘Site’ (premotor and vertex) and ‘Condition’ (Amusement, Disgust, Fear Triumph, Rotated, Rest). These t contrasts reflect the difference between pre- and post-stimulation, and such that effects of the Site and Condition factors in fact reflect the interaction of these factors with the effect of Session (pre- vs. post-stimulation). A ‘Site’ × ‘Session’ interaction was observed in inferior frontal gyri, left middle frontal gyrus and right insula cortex and finally in right precentral gyrus. A second set of clusters lay in bilateral inferior parietal cortex and postcentral gyrus on the right, left supplementary motor area extending into superior frontal gyrus. Finally a set of midline clusters were seen in right middle cingulate cortex, precuneus and parahippocampal gyrus. (A) A t-test revealed greater activity for the comparison of PMv post-stimulation compared to PMv pre-stimulation, than vertex post-stimulation compared to vertex pre-stimulation, in left inferior frontal gyrus, left supplementary motor area, cerebellar vermis, right parahippocampal gyrus, bilateral inferior parietal lobe, bilateral superior and right middle frontal gyri and right postcentral gyrus (B). The opposite comparison was associated with activity in left hippocampus, right middle cingulate cortex, right precuneus, left supramarginal gyrus, right supplementary motor area, right inferior frontal gyrus and right rolandic operculum (C).