FIGURE 3.

Region of interest analysis reveals three distinct response profiles in response to cTBS to premotor cortex. In order to look at the response profiles of the regions revealed by the ‘Site’ × ‘Session’ interaction, mean parameter estimates were extracted from each cluster and are displayed in (A–K) where positive values indicate greater activity post-stimulation compared to pre-stimulation (i.e., increased activity following cTBS) and negative values indicate a reduction in activity following cTBS. This approach revealed one network of regions that show increased levels of activity following stimulation to right PMv including supplementary motor area, inferior parietal cortex, bilateral inferior frontal gyrus, superior frontal gyrus and post central gyrus lying close to the PMv target site (graphs A–F). In contrast to this, two distinct regions of the precuneus, cingulate cortex and right IFG displayed a reduction in activity following stimulation to premotor cortex (graphs H–K) and less activity following premotor stimulation compared to following vertex stimulation. A third and final response profile was observed in a single cluster in left supramarginal gyrus whereby activity was greater post-stimulation at both sites, compared to pre-stimulation (G).