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The schematic of airway neurogenic inflammation induced by HCl intra-esophageal perfusion regulated by the DVC. The stimulation of HCl reflux into the lower esophagus was input via the vagus nerve to the nuclei in the medulla oblongata, especially NTS and DMV, and the integrated information was output via the vagus nerve into the airway to induce changes in airway neurogenic inflammation.
