Table 4.

Multivariate Cox proportional hazard analysis of the primary combined endpoint.

	Multivariable Cox proportional hazard analysis*
Endpoint	HR	95%CI	p-value (Wald test)
rs12566888†
Combined endpoint	1.69	0.87, 3.27	0.122
Myocardial infarction	1.67	0.74, 3.77	0.221
All cause mortality	2.10	0.73, 6.09	0.170
rs2768759‡
Combined endpoint	3.16	1.4, 7.13	0.006
Myocardial infarction	3.44	1.3, 9.11	0.013
All cause mortality	3.62	1.0, 13.12	0.051
rs41273215‡
Combined endpoint	0.76	0.38, 1.54	0.451
Myocardial infarction	0.92	0.4, 2.14	0.849
All cause mortality	0.52	0.14, 1.91	0.328

^*With covariates P2Y12 antagonist, reason for admission (stable CAD/type of ACS), arterial hypertension, hyperlipidemia, smoking, diabetes mellitus, medication (ASA, ACE inhibitors, beta blockers, statins), age, gender, and LVEF.

^†hc of major allele vs. minor allele carriers (dominant model).

^‡Major allele carriers vs. hc of minor allele (recessive model).