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. 2018 May 15;9:509. doi: 10.3389/fphar.2018.00509

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Copyright © 2018 He, Zhou, Zhao, Zhang, Deng, Chen, Gu, Li and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The analgesic effects of morphine (i.t., 20 μg/kg) on TCI-induced mechanical allodynia. (A) Experimental paradigms. (B) Comparisons of PWT of ipsilateral hind paws of rats in the TCI + Vehicle group and the TCI + Morphine group (n = 6 rats in each group). (C) Comparisons of MPE of rats in the Sham + Morphine group and the TCI + Morphine group (n = 6 rats in each group) following morphine administration from POD 8 to POD 14. Data are expressed as the mean ± SEM. ^###p < 0.001 versus the TCI + Vehicle group and ^∗∗∗p < 0.001 versus the Sham + Morphine group.