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. 2018 May 15;9:509. doi: 10.3389/fphar.2018.00509

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Copyright © 2018 He, Zhou, Zhao, Zhang, Deng, Chen, Gu, Li and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SAHA administration attenuated morphine tolerance in BCP. (A) Experimental paradigms. (B) Comparisons of PWT of rats in the TCI + SAHA + Vehicle and the TCI + Vehicle group (n = 6 rats in each group). (C) Comparisons of PWT of rats in the TCI + Morphine + Vehicle and the TCI + Morphine + SAHA group (n = 6 rats in each group). (D) Comparisons of PWT of rats in the TCI + SAHA + Vehicle and the TCI + Morphine + SAHA group (n = 6 rats in each group). (E) Comparisons of MPE of rats in the TCI + Morphine + Vehicle and the TCI + Morphine + SAHA (n = 6 rats in each group). Data are expressed as the mean ± SEM. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus the TCI + Vehicle group, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001 versus the TCI + morphine + Vehicle group, *p < 0.05, **p < 0.01, ***p < 0.001 versus the TCI + SAHA + Vehicle group.