Table 3.
Summary of the subgroup analyses in this meta-analysis.
| Comparisons | Category | Category | Studies | OR (95% CI) | P-value | P for heterogeneity | I2(%) |
|---|---|---|---|---|---|---|---|
| A vs. G | Ethnicity | Asian | 12 | 1.46(1.16, 1.85) | 0.002 | 0.054 | 32.8 |
| Caucasian | 8 | 0.72(0.53, 0.99) | 0.043 | 0.106 | 56.4 | ||
| SOC | HB | 13 | 1.26(0.97, 1.64) | 0.084 | 0.117 | 55.3 | |
| PB | 7 | 0.77(0.49, 1.22) | 0.271 | 0.265 | 77.2 | ||
| HWE | Positive | 14 | 1.19(0.90, 1.59) | 0.226 | 0.183 | 65.7 | |
| Negative | 6 | 0.76(0.57, 1.00) | 0.051 | 0.019 | 14.8 | ||
| Genotyping | PCR-RFLR | 3 | 0.80(0.35, 1.80) | 0.582 | 0.299 | 58.6 | |
| Sequencing | 5 | 0.80(0.45, 1.43) | 0.455 | 0.223 | 53.7 | ||
| TagMan | 5 | 0.86(0.62, 1.19) | 0.355 | 0.063 | 47.8 | ||
| Other methods | 7 | 1.54(1.04, 2.30) | 0.033 | 0.200 | 71.1 | ||
| NOS score | 5 ≤ Score ≤ 6 | 14 | 1.22(0.97, 1.53) | 0.054 | 0.047 | 42.5 | |
| Score > 6 | 6 | 0.75(0.41, 1.37) | 0.185 | <0.001 | 83.2 | ||
| GA+AA vs. GG | Ethnicity | Asian | 12 | 1.46(1.11, 1.91) | 0.007 | 0.086 | 40.4 |
| Caucasian | 8 | 0.73(0.54, 0.99) | 0.043 | 0.082 | 47.3 | ||
| SOC | HB | 13 | 1.25(0.95, 1.65) | 0.111 | 0.122 | 52.6 | |
| PB | 7 | 0.79(0.50, 1.24) | 0.301 | 0.253 | 69.6 | ||
| HWE | Positive | 14 | 1.16(0.85, 1.57) | 0.357 | 0.216 | 67.0 | |
| Negative | 6 | 0.80(0.62, 1.04) | 0.095 | <0.001 | 0.0 | ||
| Genotyping | PCR-RFLR | 3 | 0.81(0.36, 1.83) | 0.606 | 0.291 | 56.8 | |
| Sequencing | 5 | 0.80(0.42, 1.50) | 0.479 | 0.262 | 51.8 | ||
| TagMan | 5 | 0.87(0.66, 1.15) | 0.333 | 0.025 | 24.1 | ||
| Other methods | 7 | 1.53(0.99, 2.36) | 0.054 | 0.243 | 72.6 | ||
| NOS score | 5 ≤ Score ≤ 6 | 14 | 1.20(0.95, 1.50) | 0.120 | 0.105 | 33.8 | |
| Score >6 | 6 | 0.77(0.41, 1.45) | 0.414 | <0.001 | 82.8 | ||
| AA vs. GA+GG | Ethnicity | Asian | 7 | 2.41(1.16, 4.98) | 0.018 | 0.300 | 17.1 |
| Caucasian | 6 | 0.51(0.23, 1.12) | 0.095 | 0.040 | 57.2 | ||
| SOC | HB | 8 | 1.50(0.84, 2.67) | 0.172 | 0.021 | 57.5 | |
| PB | 5 | 0.53(0.19, 1.48) | 0.226 | 0.673 | 0.0 | ||
| HWE | Positive | 7 | 3.82(1.69, 8.61) | 0.001 | 0.172 | 33.6 | |
| Negative | 6 | 0.45(0.21, 0.93) | 0.031 | 0.457 | 0.0 | ||
| Genotyping | PCR-RFLR | 1 | 0.58(0.02, 14.52) | 0.741 | N/A | N/A | |
| Sequencing | 4 | 0.86(0.33, 2.25) | 0.761 | 0.835 | 0.0 | ||
| TagMan | 4 | 0.61(0.26, 1.42) | 0.247 | 0.012 | 72.5 | ||
| Other methods | 4 | 3.43(1.37, 8.61) | 0.009 | 0.127 | 47.4 | ||
| NOS score | 5 ≤ Score ≤ 6 | 8 | 1.50(0.84, 2.67) | 0.172 | 0.021 | 57.5 | |
| Score>6 | 5 | 0.53(0.19, 1.48) | 0.226 | 0.673 | 0.0 | ||
| AA vs. GG | Ethnicity | Asian | 7 | 2.41(1.17, 4.98) | 0.018 | 0.291 | 18.3 |
| Caucasian | 6 | 0.50(0.23, 1.10) | 0.084 | 0.039 | 57.4 | ||
| SOC | HB | 8 | 1.50(0.84, 2.67) | 0.171 | 0.021 | 57.6 | |
| PB | 5 | 0.51(0.18, 1.43) | 0.199 | 0.641 | 0.0 | ||
| HWE | Positive | 7 | 3.68(1.64, 8.28) | 0.002 | 0.146 | 37.0 | |
| Negative | 6 | 0.44(0.21, 0.92) | 0.029 | 0.446 | 0.0 | ||
| Genotyping | PCR-RFLR | 1 | 0.53(0.02, 13.30) | 0.700 | N/A | N/A | |
| Sequencing | 4 | 0.85(0.33, 2.21) | 0.740 | 0.794 | 0.0 | ||
| TagMan | 4 | 0.60(0.26, 1.40) | 0.236 | 0.013 | 72.4 | ||
| Other methods | 4 | 3.40(1.36, 8.47) | 0.009 | 0.121 | 48.4 | ||
| NOS score | 5 ≤ Score ≤ 6 | 8 | 1.50(0.84, 2.67) | 0.171 | 0.021 | 57.6 | |
| Score>6 | 5 | 0.51(0.18, 1.43) | 0.199 | 0.641 | 0.0 | ||
| GA vs. GG | Ethnicity | Asian | 12 | 1.40(1.03, 1.91) | 0.032 | 0.032 | 48.0 |
| Caucasian | 8 | 0.76(0.57, 1.01) | 0.057 | 0.115 | 39.6 | ||
| SOC | HB | 13 | 1.21(0.90, 1.63) | 0.210 | 0.011 | 53.7 | |
| PB | 7 | 0.82(0.53, 1.26) | 0.358 | 0.009 | 64.9 | ||
| HWE | Positive | 14 | 1.09(0.80, 1.50) | 0.585 | <0.001 | 67.6 | |
| Negative | 6 | 0.87(0.66, 1.15) | 0.322 | 0.466 | 0.0 | ||
| Genotyping | PCR-RFLR | 3 | 0.84(0.38, 1.82) | 0.651 | 0.651 | 52.6 | |
| Sequencing | 5 | 0.80(0.39, 1.66) | 0.553 | 0.553 | 49.0 | ||
| TagMan | 5 | 0.90(0.69, 1.16) | 0.411 | 0.411 | 7.6 | ||
| Other methods | 7 | 1.43(0.91, 2.26) | 0.120 | 0.120 | 73.9 | ||
| NOS score | 5 ≤ Score ≤ 6 | 14 | 1.16(0.91, 1.47) | 0.233 | 0.096 | 34.9 | |
| Score>6 | 6 | 0.80(0.43, 1.48) | 0.473 | <0.001 | 80.8 |
SOC, source of controls; PB, population-based controls; HB, hospital-based controls; NOS, Newcastle-Ottawa Scale; HWE, Hardy–Weinberg equilibrium; PCR-RFLR, PCR-restriction fragment length polymorphism. Bold values are statistically significant (P < 0.05).