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. 2018 May 15;12:324. doi: 10.3389/fnins.2018.00324

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Copyright © 2018 Chen, Cheng, Chu, Zhang, Dong, Lou, Zhu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATPγS induced macropinosomes in Drosophila embryonic hemocytes. (A) Hemocytes (green) uptook fluorescent dextrans ranged from 3-kDa (TRD3S) to 70-kDa (TRD70S) dextrans and generated macropinosomes (arrows). (B) Success rates were defined as the percentage of embryos where hemocytes with macropinosomes 1.5 h after completion of different-sized dextrans injected. (C) Numbers (#) of macropinosomes in each hemocyte. P-values were calculated using one-way ANOVA among groups; n.s.: non-significant. (D) The size-distribution pattern of macropinosomes containing TRD3S (n = 100 macropinosomes, from 11 embryos). (E) Both TRITC labeled (red, TRD3S) and cascade blue labeled (blue, CB3S) dextrans were feasible to be uptaken by GFP-positive hemocytes (green), and formed macropinosomes (arrows). (F) In-depth 3D reconstruction analysis of ATPγS induced macropinosomes using a spatial deconvolution. Note that TRD70S dextran (red) labeled macropinosomes (red) and their surrounding GFP-positive microtubule-structures (green). Images were displayed in x-y (top), x-z (bottom), and y-z (right) projections. Scale bars, 10 μm.