Table II.
CAIX and Tie2 expression in gastric cancer (n=76).
| CAIX, n (%) | Tie2, n (%) | ||||||
|---|---|---|---|---|---|---|---|
| Characteristics | − | + | ++ | − | + | ++ | P-value |
| Tumor sizea | NS | ||||||
| T1 | 2 (100.0) | 0 | 0 | 2 (100.0) | 0 | 0 | |
| T2 | 3 (25.0) | 8 (66.7) | 1 (8.3) | 3 (25.0) | 9 (75.0) | 0 | |
| T3 | 5 (9.4) | 13 (24.5) | 35 (66.0) | 5 (9.4) | 24 (45.3) | 24 (45.3) | |
| T4 | 0 | 0 | 9 (100.0) | 0 | 2 (22.2) | 7 (77.8) | |
| Lymph nodesb | NS | ||||||
| N0 | 9 (50.0) | 6 (33.3) | 3 (16.7) | 10 (55.6) | 6 (33.3) | 2 (11.1) | |
| N1 | 1 (3.6) | 15 (53.6) | 12 (42.9) | 1 (3.6) | 21 (75.0) | 6 (21.4) | |
| N2 | 0 | 2 (8.0) | 23 (92.0) | 0 | 8 (32.0) | 17 (68.0) | |
| N3 | 0 | 0 | 5 (100.0) | 0 | 0 | 5 (100.0) | |
| TNM stage | NS | ||||||
| I | 5 (55.5) | 4 (44.4) | 0 | 5 (55.5) | 4 (44.4) | 0 | |
| II | 4 (33.3) | 6 (50.0) | 2 (16.7) | 4 (33.3) | 6 (50.0) | 2 (16.7) | |
| III | 1 (2.4) | 11 (26.2) | 30 (71.4) | 1 (2.4) | 24 (57.1) | 17 (40.5) | |
| IV | 0 | 0 | 13 (100.0) | 0 | 1 (7.7) | 12 (92.3) | |
| Histological grade | NS | ||||||
| I | 2 (20.0) | 2 (20.0) | 6 (60.0) | 2 (20.0) | 2 (20.0) | 6 (60.0) | |
| II | 3 (14.3) | 9 (42.9) | 9 (42.9) | 4 (19.1) | 11 (52.4) | 6 (28.6) | |
| III | 5 (11.1) | 14 (31.1) | 26 (57.8) | 5 (11.1) | 19 (42.2) | 21 (46.7) | |
P-values were obtained using the Fisher's exact test. NS, not significant; Tie2, Tunica Interna endothelial cell kinase; CAIX, carbonic anhydrase IX.
a
T1, The tumor is immersed in the basement membrane or submucosa. T2, The tumor is immersed in the muscle film or subserous membrane. T3, The tumor penetrates the serous membrane but does not infiltrate the adjacent tissue. T4, Tumor infiltration adjacent tissue.
b
N0, No lymph node metastasis. N1, There are 1–6 regional lymph node metastases. N2, There are 7 to 15 regional lymph node metastases. N3, There are more than 15 regional lymph node metastases.