Figure 7.

HOTAIR inhibition suppresses tumor growth in xenograft models. Xenograft mouse model was created by subcutaneous injection of HepG2 cells pretreated with or without HOTAIR siRNA lentiviral vectors to nude mouse. (A) Five primary tumors from each group were photographed after sacrifice at 30th day. (B) Tumor growth curves in two groups were shown every 6 days until the 30th day following cells injection. (C and D) The expression of HPTAIR and miR-217 in primary tumor tissues was measured by qRT-PCR. (E and F) The expression of HPTAIR and miR-217 in primary tumor tissues was measured by northern blotting. (G and H) The expression of Ki67 and PCNA in primary tumor tissues was visualized by immunohistochemistry (*P<0.05, **P<0.01). HOTAIR, HOX transcript antisense RNA. miR-217, microRNA-217.