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. 2018 Mar 9;15(5):4298–4308. doi: 10.3892/etm.2018.5941

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Histopathologic analysis of the therapeutic effects of rBMP-2/Fc in steroid-induced osteonecrosis of the femoral head in a mouse model. (A) Analysis of the (A) body weights and (B) spleen weights of mice following 30-days treatment with PBS, DEX or rBMP-2/Fc. (C) The vascular density of the femoral head in mice treated with PBS, DEX or rBMP-2/Fc was determined via Factor VIII staining of the vascular area. (D) Evaluation of bone reabsorption activity of the ischemic femoral head in mice treated with PBS, DEX or rBMP-2/Fc as determined by cluster of differentiation 68 staining. (E) Images of the smooth articular surface and (F) the well-preserved secondary ossification center in mice treated with PBS, DEX or rBMP-2/Fc were used to determine histopathologic analysis. Magnification, 40×. The mRNA expression of the angiogenesis factors (G) ICAM-1 and (H) PD-ECGF in synovial cells in experimental mice as determined by reverse transcription-quantitative polymerase chain reaction. *P<0.05; **P<0.01. BMP-2, bone morphogenetic protein-2; rBMP, recombinant bone morphogenetic protein; Fc, Fc fragment; DEX, dexamethasone; ICAM-1, intercellular adhesion molecule 1; PD-ECGF, platelet-derived endothelial cell growth factor.