Table 1.

Subcutaneous Continuous Infusion Dosing Paradigm

Group	Loading dose (15 min post-injury)	Osmotic pump (immediate)
Sham	None	None
Vehicle	Saline s.c.	Saline
	Cremophor i.p.	Cremphor
Phenelzine	10 mg/kg s.c. PZ	10 mg/kg/day/3 days PZ
	Cremophor i.p.	Cremophor
Cyclosporine A	Saline s.c.	Saline
	20 mg/kg i.p. CsA	10 mg/kg/day/3 days CsA
Phenelzine + Cyclosporine A	10 mg/kg s.c. PZ	10 mg/kg/day/3 days PZ
	20 mg/kg i.p. CsA	10 mg/kg/day/3 days CsA

Demonstration of the subcutaneous continuous infusion dosing paradigm followed. Osmotic pumps were placed subcutaneously immediately following impact injury and closure of the craniotomy site. Pumps were removed 72 h later at the time of euthanasia. Loading doses were administered 15 min following impact. Cremophor (saline/650 mg cremophor/32.9% ethanol/mL) was prepared to deliver an equal amount cremophor as received by CsA animals. Saline was prepared to deliver an equal amount of saline as PZ animals.

PZ, phenelzine (in saline); CsA, cyclosporine A (in saline/650 mg cremophor/32.9% ethanol/mL); s.c., subcutaneous, i.p., intraperitoneal.