. 2018 Jun 1;35(11):1280–1293. doi: 10.1089/neu.2017.5353

Table 3.

Summary of Results: Subcutaneous Continuous Infusion Dosing Paradigm

	Vehicle	PZ	CsA	PZ + CsA
Mitochondrial RCR	↓^*	↔^	↓^*	↓^*
Mitochondrial individual respiratory states	↓^*	↓^*	↓^*	↓^*
Mitochondrial 4-HNE	↑^*	↓^#	↓^#	↑^*
Mitochondrial acrolein	↑^*	↔^	↔^	↑^*
Spectrin degradation	↑^*	↔^	↑^*	↔^

Effect of the 15 min post-injury loading dose +72 h subcutaneous continuous infusion dosing paradigm on the above listed outcome measures 72 h following severe cortical impact injury. Vehicle (15 min post-injury bolus dose: intraperitoneal cremophor/ethanol/saline; 15 min post-injury bolus dose: subcutaneous saline; subcutaneous osmotic pump: cremophor/ethanol/saline; subcutaneous osmotic pump: saline). PZ (15 min post-injury bolus dose: intraperitoneal cremophor/ethanol/saline; 15 min post-injury bolus dose: subcutaneous 10 mg/kg PZ in saline; subcutaneous osmotic pump: cremophor/ethanol/saline; subcutaneous osmotic pump: 10 mg/kg/day/3 days PZ in saline). CsA (15 min post-injury bolus dose: intraperitoneal 20 mg/kg CsA in cremophor/ethanol/saline; 15 min post-injury bolus dose: subcutaneous saline; subcutaneous osmotic pump: 10 mg/kg/day/3 days CsA in cremophor/ethanol/saline; subcutaneous osmotic pump: saline). PZ + CsA (15 min post-injury bolus dose: intraperitoneal 20 mg/kg CsA in cremophor/ethanol/saline; 15 min post-injury bolus dose: subcutaneous 10 mg/kg PZ in saline; subcutaneous osmotic pump: 10 mg/kg/day/3 days CsA in cremophor/ethanol/saline; subcutaneous osmotic pump: 10 mg/kg/day/3 days PZ in saline).

PZ, phenelzine; CsA, cyclosporine A; RCR, respiratory control ratio (state III/state IV); 4-HNE, 4-hydroxynonenal; ↓^* = significantly decreased from sham, ↑^* = significantly increased from sham, ↓# = significantly decreased from vehicle, ↔^ = not significantly different from sham.