Table 4.

Spectrin Degradation: Phenelzine Continuous Infusion Vs. Phenelzine Intermittent Dosing

	PZCI	PZID
Spectrin degradation	↔^	↑*

Comparison of the effect of the PZ continuous infusion dosing paradigm versus the PZ intermittent dosing paradigm on α-spectrin degradation 72h following severe cortical impact injury. PZ_CI = phenelzine continuous infusion (15min post-injury bolus dose: intraperitoneal cremophor/ethanol/saline, 15min post-injury bolus dose: subcutaneous 10mg/kg PZ in saline, Subcutaneous osmotic pump: cremophor/ethanol/saline, Subcutaneous osmotic pump: 10mg/kg/day/3d PZ in saline). PZ_ID = phenelzine intermittent dosing (15min post-injury subcutaneous bolus dose of 10mg/kg PZ in saline followed by subcutaneous bolus dose of 5mg/kg PZ in saline every 12h up to and including 60h). ↑^* = significantly increased from sham,

PZ_CI, continuous infusion; PZ_ID, intermittent dosing.