FIG. 4.

Effect of MCC950 on TXNIP expression at 24 h post-TBI. Representative and quantitative analysis of western blots showed that TXNIP expression increased significantly at 24 h in saline-treated TBI mice compared to shams. MCC950 treatment at post-injury induced a minimal decrease in TXNIP levels. Values are expressed as mean ± SEM (n = 8). *p < 0.05 versus sham. GAPDH, glyceraldehyde 3-phosphate dehydrogenase; SEM, standard error of the mean; TBI, traumatic brain injury; TXNIP, thioredoxin interacting protein.