FIG. 5.

Effect of MCC950 on Akt phosphorylation at 24 h post-TBI. Representative and quantitative analysis showed significant elevation in Akt activity as determined by pAkt/Akt ratio in TBI saline-treated and MCC950-treated animals compared to shams. Akt activation was not significantly increased with MCC950 treatment compared to saline TBI only. Values are expressed as mean ± SEM (n = 8). *p < 0.05 versus sham. Akt, protein kinase B; pAkt, phosphorylated Akt; SEM, standard error of the mean; TBI, traumatic brain injury.